GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs428445 | 1 | rs13041953 | chr20:55081353 | C20orf43 | chr20:55043647-55093942:+ | 0.18 | 4.88 | 1.22E-6 | Refractive astigmatism |
| BRCA | cis | rs428445 | 1 | rs13043526 | chr20:55088798 | C20orf43 | chr20:55043647-55093942:+ | 0.16 | 4.54 | 6.38E-6 | Refractive astigmatism |
| BRCA | cis | rs13053175 | 1 | rs13053175 | chr22:37613309 | ANKRD54 | chr22:38226863-38240303:- | 0.11 | 3.49 | 0.000506 | Longevity |
| BRCA | cis | rs13053175 | 1 | rs13053175 | chr22:37613309 | NOL12 | chr22:38082344-38089484:+ | 0.09 | 3.5 | 0.000489 | Longevity |
| BRCA | cis | rs13053175 | 1 | rs13053175 | chr22:37613309 | PICK1 | chr22:38453262-38471707:+ | 0.1 | 3.62 | 0.000306 | Longevity |
| BRCA | cis | rs13053175 | 1 | rs13053175 | chr22:37613309 | TXN2 | chr22:36863093-36877687:- | 0.1 | 3.42 | 0.000657 | Longevity |
| BRCA | cis | rs4820539 | 1 | rs13054985 | chr22:23458577 | RTDR1 | chr22:23401594-23484241:- | -0.17 | -4.43 | 1.04E-5 | Bone mineral density |
| BRCA | cis | rs3796352 | 1 | rs13058817 | chr3:53024139 | NT5DC2 | chr3:52558386-52569093:- | -0.18 | -3.8 | 0.000154 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs13058817 | chr3:53024139 | RFT1 | chr3:53122503-53164470:- | 0.31 | 4.38 | 1.33E-5 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs13058817 | chr3:53024139 | TMEM110 | chr3:52867139-52931547:- | 0.31 | 4.87 | 1.3E-6 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs10935120 | 1 | rs13059720 | chr3:134242021 | ANAPC13 | chr3:134196547-134204865:- | -0.41 | -13.31 | 1.63E-37 | Height |
| BRCA | cis | rs10935120 | 1 | rs13059720 | chr3:134242021 | CEP63 | chr3:134204575-134293852:+ | -0.14 | -3.78 | 0.000166 | Height |
| BRCA | cis | rs4679904 | 1 | rs13065269 | chr3:160352319 | TRIM59 | chr3:160153292-160167626:- | 0.13 | 3.91 | 9.83E-5 | Primary biliary cirrhosis |
| BRCA | cis | rs13067306 | 1 | rs13067306 | chr3:94243713 | DHFRL1 | chr3:93776770-93782067:- | -0.16 | -3.71 | 0.000221 | Blood pressure measurement (high sodium intervention) |
| BRCA | cis | rs73201462 | 1 | rs13069054 | chr3:127855982 | RUVBL1 | chr3:127783627-127872757:- | 0.14 | 3.39 | 0.000724 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |